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Dr. Poullos is a native of Stockton California. He earned his B.S. at Santa Clara University and M.D. degree at the University of Texas Medical School at Houston, after which he did an Internal Medicine residency at the University of California-San Francisco, finishing in 2002. He stayed at UCSF as a Gastroenterology fellow until 2004. However, after a spinal cord injury, he decided to retrain in Radiology. He did his Radiology residency at Stanford University, where he also completed a fellowship In Body Imaging in 2009. Dr. Poullos is now faculty in both the departments of Radiology and Gastroenterology and Hepatology.

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