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Paul Nyquist MD, MPH, is a professor of neurology, anesthesiology & critical care medicine and neurosurgery at the Johns Hopkins University School of Medicine. He is a clinician and researcher who has gained national and international prominence as part of a community of neurocritical care, intensive care, and cerebrovascular neurologists. Dr. Nyquist is PI on the NIH-funded "Vascular Contributions to Blood Brain Barrier Permeability and regional White Matter Hyperintensity Progression in Young Asymptomatic People." He is a Senior Consultant at the NIH CCMD intramural program. He cares for patients who are transported to the Johns Hopkins NCCU from around the world and is a recognized clinical leader in neurocritical care and stroke. He also has a unique expertise in military operational medicine and diving medicine and was trained as an undersea medical officer and a diving medical officer in the United States Navy and achieved the rank of lieutenant commander. He has held leadership positions in national and international societies including the board of directors of the Neurocritical Care Society and the UCNS executive board. He has been the chair of various sections of the AAN, SCCM, and ANA. He attends in the NCCU and intermittently on the inpatient stroke service. He is the primary senior clinical NCCU consultant of the NIH CCMD critical care program and is the official NCCU liaison to that program. 

Dr. Nyquist is a translational researcher focused on brain injury and systems biology. He studies ischemic white matter disease and cerebrovascular conditions. He was trained as a Navy deep-sea diver and is an expert on decompression illness. While in the Navy, he was a project officer and principal investigator at the Navy Medical Research Institute, where he held leadership positions in key human decompression trials and completed important research on the effects of diving on complement activation in human divers. He is presently a co-PI on a thermal stress project funded by the Navy through the Johns Hopkins Applied Physics Laboratory. He is a member of large international genomic research consortia, including the NEUROCHARGE consortium, the International Stroke Genetics Consortium, and TOPMED. He has also held positions on the steering committee and scientific committee of the ISGC. He is a past NIH RO-1 funded principal investigator and has been a co-investigator on numerous RO-1s. He has been funded through industry and has run numerous national and international clinical trials at Johns Hopkins as site PI, including many large multi-centered international trials such as the SWISS, IMS3, FAST, and DIAS as a co-investigator or site PI. 

Dr. Nyquist has received numerous awards and recognitions for his clinical and scientific efforts. These include a United Nations Community Service award, Navy commendations, and a young investigator award. He has been an NIH RO-1 funded principal investigator. He has been an NIH grant reviewer as well as a grant reviewer for Navy white papers, for the Italian Ministry of Health, the Dutch AHA, the Johns Hopkins ICTR, the ACCM seed grants program, and for the French government. He is a member of the SCCM’s grant review scientific committee. 

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